Psoriasis: Study lays foundation for new treatment strategy

About one third of those who suffer from psoriasis develop inflammation in their joints (psoriatic arthritis) as a result of the chronic skin condition. A research team has now discovered a key starting point for inhibiting inflammation in both psoriasis and psoriatic arthritis. The researchers’ findings may form the basis for developing new treatment, diagnostic and prevention strategies.
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New study shows genes can predict response to arthritis treatment and paves the way for future drug development

New research has shown that molecular profiling of the diseased joint tissue can significantly impact whether specific drug treatments will work to treat rheumatoid arthritis (RA) patients. The researchers also identified specific genes associated with resistance to most available drugs therapies, commonly referred to as refractory disease, which could provide the key to developing new, successful drugs to help these people.
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Predicting the progression of rheumatoid arthritis

Researchers evaluated the ability of a polygenic risk score constructed from a genome-wide association study of rheumatoid arthritis susceptibility to predict radiographic progression, which is indicative of structural joint damage in individuals with rheumatoid arthritis. The research team identified an association between the polygenic risk score and radiographic progression, an observation that was pronounced in people with a younger age of onset of rheumatoid arthritis.
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Scientists discover link between gut microbiota and chronic inflammatory diseases like arthritis

An international research team has established a link between gut microbiota and chronic inflammatory diseases such as arthritis. The team has discovered that a protein naturally present in the gut acts on the microbiota and causes the formation of molecules that exacerbate the symptoms of these diseases.
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