TSRI scientists give new superpowers to lifesaving antibiotic

May 30, 2017

Scientists at The Scripps Research Institute (TSRI) have given new superpowers to a lifesaving antibiotic called vancomycin, an advance that could eliminate the threat of antibiotic-resistant infections for years to come. The researchers, led by Dale Boger, co-chair of TSRI’s Department of Chemistry, discovered a way to structurally modify vancomycin to make an already-powerful version of the antibiotic even more potent.

“Doctors could use this modified form of vancomycin without fear of resistance emerging,” said Boger, whose team announced the finding today in the journal Proceedings of the National Academy of Sciences.

Scripps scientists make important advance in HIV vaccine design

May 29, 2017

Scientists at The Scripps Research Institute (TSRI) have made another important advance in HIV vaccine design. The development was possible thanks to previous studies at TSRI showing the structures of a protein on HIV’s surface, called the envelope glycoprotein. The scientists used these structures to design a mimic of the viral protein from a different HIV subtype, subtype C, which is responsible for the majority of infections worldwide.

The new immunogen is now part of a growing library of TSRI-designed immunogens that could one day be combined in a vaccine to combat many strains of HIV.

Sri Lanka's flood survivors threatened by dengue, disease: aid workers

By Nita Bhalla

NEW DELHI (Thomson Reuters Foundation) – Thousands of survivors of devastating floods and landslides in Sri Lanka are at risk of potentially fatal diseases such as dengue fever, charities warned on Monday as the death toll from the disaster continued to rise.

Torrential rains over the last four days have sparked widespread flooding and triggered landslides in southwestern parts of the Indian Ocean island. At least 177 people have died and almost half a million others have had their lives disrupted.

Drug for refractory psoriatic arthritis shows promise in clinical trial

Patients with psoriatic arthritis for whom standard-of-care pharmaceutical treatments have provided no lasting relief experienced a significant reduction in symptoms, including joint tenderness and swelling, have reported promising results when they were given a new drug.
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Bulgaria to conduct food product checks amid quality concerns

Bulgaria said on Saturday it would conduct checks on different food products of multinational companies sold in the Balkan state and compare them with food sold in richer western European countries, amid concerns over quality.

Consumer groups have complained that popular brands use poorer-quality ingredients in products sold in central and eastern Europe than in countries like Germany and Austria.

However, they have had little recourse to complain because the European Union only requires that the packaging contain a clear list of all ingredients.

FFR-CT Accuracy; TnT Assay 'Sense and Sensitivity'; Chocolate Lessens Afib?

Computed tomography–derived fractional flow reserve (FFR-CT) accuracy varies across the spectrum of disease severity as compared with invasive FFR, with the most accurate results found in the upper or lower ranges of cardiac ischemia, a systematic review of five studies with 536 patients reported in JAMA Cardiology.

“In this study, for vessels with FFR-CT values above 0.90, 97.9% met the invasive FFR guideline criterion for deferral (FFR>0.80). At the other end of the spectrum, for vessels with FFR-CT values below 0.60, 86.4% met the invasive FFR guideline criterion for stenting (FFR≤0.80),” the researchers wrote. “In between, FFR-CT gave less certainty as to whether the invasive FFR will meet the stenting criterion.

Alzheimer's Deaths Jump 55 Percent: CDC

News Picture: Alzheimer's Deaths Jump 55 Percent: CDCBy Steven Reinberg
HealthDay Reporter

Latest Alzheimers News

THURSDAY, May 25, 2017 (HealthDay News) — As more baby boomers age, deaths from Alzheimer’s disease have jumped 55 percent, and in a quarter of those cases the heavy burden of caregiving has fallen on loved ones, U.S. health officials report.

“Alzheimer’s disease is a public health problem that affects not only people with Alzheimer’s disease, but also the people who provide care to them, which is often family members,” said report author Christopher Taylor. He’s an epidemiologist at the National Center for Chronic Disease Prevention and Health Promotion.

Molina Healthcare, A Top Obamacare Insurer, Investigates Breach Of Patients’ Data

Molina Healthcare, a major insurer in Medicaid and state exchanges across the country, has shut down its online patient portal as it investigates a potential data breach that may have exposed sensitive medical information.

The company said Friday that it closed the online portal for medical claims and other customer information while it examined a “security vulnerability.” It’s not clear how many patient records might have been exposed and for how long. The company has more than 4.8 million customers in 12 states and Puerto Rico.