Study uncovers new pathway for treating high blood pressure, heart failure

Discovery could eventually lead to new treatments for hypertension and heart failure

National Institutes of Health, University of Maryland School of Medicine, Canadian Institutes of Health Research

New research by scientists at the University of Maryland School of Medicine (UM SOM) and the Ottawa Heart Institute has uncovered a new pathway by which the brain uses an unusual steroid to control blood pressure. The study, which also suggests new approaches for treating high blood pressure and heart failure, appears today in the journal Public Library of Science (PLOS) One.

Asbestos victims win damages ruling

MesotheliomaMesothelioma is an aggressive cancer caused by exposure to asbestos

Government plans to deduct legal fees from the damages paid to people dying from asbestos exposure are unlawful, the High Court has ruled.

The Asbestos Victims’ Support Groups Forum UK brought the action against Justice Secretary Chris Grayling.

The group challenged his decision to allow 25% of damages awarded to mesothelioma sufferers to be used to pay legal insurance premiums and costs.

The Ministry of Justice said it was “disappointed” with the judgment.

Smell test 'may predict lifespan'

By Smitha Mundasad
Health reporter, BBC News

person smelling flowers People who did well on smell tests were most likely to be alive five years later

Measuring people’s sense of smell in later life could help doctors predict how likely they are to be alive in five years’ time, a PLOS One study suggests.

A survey of 3,000 adults found 39% with the poorest sense of smell were dead within five years – compared to just 10% who identified odours correctly.

Up to 18 exposed to U.S. Ebola patient, including children

Texas Governor Rick Perry speaks at a media conference at Texas Health Presbyterian Hospital in Dallas, Texas October 1, 2014.   REUTERS/Mike Stone

(Reuters) – Health experts were observing up to 18 people, including children, who had contact with the first person to be diagnosed with the deadly Ebola virus in the United States, officials said on Wednesday.

Confirmation that a man who flew to Texas from Liberia later fell ill with the hemorrhagic fever prompted U.S. health officials to take steps to contain the virus, which has killed at least 3,338 people in Liberia, Sierra Leone and Guinea, the World Health Organization said.

Ebola deaths reach 3,338, but widely undercounted, WHO says

A burial team wearing protective clothing prepare the body of a person suspected to have died of the Ebola virus for interment, in Freetown September 28, 2014.  REUTERS/Christopher Black/WHO/Handout via Reuters

A burial team wearing protective clothing prepare the body of a person suspected to have died of the Ebola virus for interment, in Freetown September 28, 2014.

Credit: Reuters/Christopher Black/WHO/Handout via Reuters

(Reuters) – The death toll from the world’s worst Ebola outbreak on record reached 3,338 people out of 7,178 cases in West Africa as of Sept. 28, the World Health Organization said on Wednesday.

It said the total number of new cases had fallen for a second week, but warned against reading any good news into the figures as they were almost certainly under-reported and there were few signs of the epidemic being brought under control.

Sanofi, Regeneron report positive Phase 2 study of dupilumab in patients with CSwNP

Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) and Sanofi (EURONEXT: SAN and NYSE: SNY) today announced that a Phase 2a proof-of-concept study of dupilumab, an investigational therapy that blocks IL-4 and IL-13 signaling, met all primary and secondary endpoints in patients with moderate-to-severe chronic sinusitis with nasal polyps (CSwNP) who did not respond to intranasal corticosteroids.

“These data suggest the potential of dupilumab for use in the treatment of another allergic inflammatory condition,” said Gianluca Pirozzi, M.D., PhD, Vice President, Global Project Head at Sanofi. “Based on these results, we plan to move forward with further clinical development of dupilumab in patients with chronic sinusitis with nasal polyps, in addition to the ongoing development in atopic dermatitis and in asthma.”

Early exposure to marijuana can lead to immune-related diseases in adulthood

New research published in the Journal of Leukocyte Biology suggests that early exposure to marijuana can affect immune system development, leading to immune-related diseases in adulthood

When it comes to using marijuana, new research, involving mice and published in the October 2014 issue of the Journal of Leukocyte Biology, suggests that just because you can do it, doesn’t mean that you should. That’s because a team of Italian scientists have found that using marijuana in adolescence may do serious long-term damage to the immune system. This damage may result in autoimmune diseases and chronic inflammatory diseases, such as multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis in adulthood.