Glaxo heart drug that failed trial shows potential benefit

The GlaxoSmithKline logo is seen at the entrance of a building in Luxembourg, September 10, 2013. Picture taken September 10, 2013 REUTERS/Yves Herman

The GlaxoSmithKline logo is seen at the entrance of a building in Luxembourg, September 10, 2013. Picture taken September 10, 2013

Credit: Reuters/Yves Herman


(Reuters) – A new type of heart drug being developed by GlaxoSmithKline, which failed the main goal of a Phase III study of patients with chronic but well-treated heart disease, showed signs of potential benefit, the trial’s co-leader said.

The results presented at the American College of Cardiology scientific meeting in Washington on Sunday provided a glimmer of hope that the medicine, darapladib, may have value.

Edwards heart valve system tops Medtronic version in small study


(Reuters) – The minimally invasive aortic heart valve replacement system from Edwards Lifesciences Corp performed better than a rival product sold by Medtronic Inc in the first head-to-head study of the two, according to data from a small German trial presented at a major heart meeting on Sunday.

While the results are unlikely to be seen as decisive, given the size and limited scope of the study, they could provide the Edwards sales force with a valuable marketing tool as the two companies vie for market share with their competing transcatheter aortic valve replacement (TAVR) systems.

Nurse in court charged with murders





















Victorino Chua









Victorino Chua was remanded in custody by magistrates in Manchester








A nurse has appeared in court charged with murdering three patients at Stepping Hill Hospital in Stockport in 2011.

Victorino Chua, 48, of Churchill Street, Heaton Norris, is also charged with 31 other offences including GBH and attempted poisoning.

Senegal shuts land border with Guinea to prevent Ebola spreading


(Reuters) – Senegal closed its land border with Guinea on Saturday to try to prevent the spread of the Ebola virus, which Guinean authorities say is suspected of killing 70 people in what would be the deadliest outbreak in seven years.

The discovery of 11 people suspected to have died of Ebola in Sierra Leone and Liberia in recent days has stirred concern that one of the most lethal infectious diseases known to man could spread in a poor corner of West Africa, where health systems are ill-equipped to cope.

Amgen drug lowers cholesterol up to 66 percent in pivotal studies


(Reuters) – Amgen Inc’s drug from a high profile new class of experimental medicines lowered “bad” LDL cholesterol by 55 percent to 66 percent compared with a placebo in a trio of late-stage clinical trials, according to data presented on Saturday.

Amgen had previously said the drug, evolocumab, met the main goals of five late-stage trials involving some 4,000 patients by significantly outperforming placebo or another cholesterol medicine in a variety of patient populations.

ACC: Statins Tied to Boost in Men's Sexual Function

Meeting Coverage

Published: Mar 29, 2014

WASHINGTON — Statins appeared to improved erectile function to a clinically meaningful degree, according to a meta-analysis.

Across 11 randomized trials, the average gain in subjective score on the International Inventory of Erectile Function (IIEF) was 3.4 points versus placebo or other controls (P=0.0001).

The effect “was clinically relevant,” John Kostis, MD, of Rutgers Robert Wood Johnson Medical School in New Brunswick, N.J., told reporters at a press telebriefing in advance of presentation at the American College of Cardiology (ACC) meeting here.

Erectile dysfunction can be reversed without medication

Men suffering from sexual dysfunction can be successful at reversing their problem by focusing on lifestyle factors and not just relying on medication, according to research. Researchers have highlighted the incidence of erectile dysfunction and lack of sexual desire among Australian men aged 35-80 years.

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Reversing erectile dysfunction possible with lifestyle changes


Men suffering from sexual dysfunction can be successful at reversing their problem, by focusing on lifestyle factors and not just relying on medication, according to research at the University of Adelaide.


In a new paper published in the Journal of Sexual Medicine, researchers highlight the incidence of erectile dysfunction and lack of sexual desire among Australian men aged 35-80 years.


Over a five-year period, 31% of the 810 men involved in the study developed some form of erectile dysfunction.

U.S. FDA moves to offset shortage of common saline solution


(Reuters) – Moving to offset shortages of a common saline used in hospitals and dialysis centers, the U.S. Food and Drug Administration said on Friday that it will temporarily allow Fresenius Kabi USA LLC to distribute normal saline from its manufacturing facility in Norway.

The FDA said the initial shipments would help but not resolve shortages of 0.9 percent sodium chloride injection, also known as normal saline. The drug is widely used to treat patients with dehydration and other medical conditions.