Preventing Damaging White Blood Cells From Entering The Joints Offers Potential Strategy For Treating Rheumatoid Arthritis

Main Category: Arthritis / Rheumatology
Also Included In: Immune System / Vaccines
Article Date: 06 Mar 2012 – 1:00 PST

email icon email to a friend   printer icon printer friendly   write icon opinions  

<!– rate icon rate article



Patient / Public:not yet rated

Healthcare Prof:not yet rated

Newcastle University scientists, in work funded by Arthritis Research UK, have discovered a new way of potentially treating rheumatoid arthritis. This works by preventing damaging white blood cells cells from entering the joints.

Using a unique drug, they are able to stop destructive white blood cells migrating from the bloodstream into inflamed tissue and so preventing them causing further injury.

In rheumatoid arthritis the body’s own immune system attacks the joints. Typical approaches for treatment involve blocking the signals in the body which activate the immune system to attack the joint. In contrast, this new strategy will prevent damaging white blood cells from entering the joints in the first place.

Lead author Dr Graeme O’Boyle described the agent’s action: “Imagine that the damaged joint is covered in flags which are signalling to the white blood cells. Traditional treatments have involved pulling down the flags one by one but what we have done is use an agent which in effect ‘blindfolds’ the white blood cells. Therefore, they don’t know which way to travel and so won’t add to the damage.”

Publishing in PNAS the Newcastle University scientists describe how the agent called PS372424 prevents activated T cells, the white blood cells which cause the damage, from migrating towards the site of rheumatoid arthritis. To show the effectiveness of their new treatment, they have developed a new mouse-model of arthritis which has a human immune system. They discovered that PS372424 blocked the ability of human T cells to move towards a pouch of synovial fluid from patients with active rheumatoid arthritis.

In the work they found that PS372424 binds to a specific receptor CXCR3 which is only found on activated T cells. This targets the ‘blindfold’ to only these T cells, and leaves other white blood cells unaffected. As Dr O’Boyle explains: “By desensitising damaging white blood cells using CXCR3 they are not directed to migrate towards rheumatoid sites. The advantage of this system is that it is much more specific than current medications and may not compromise the immune system.”

Professor Alan Silman, medical director of Arthritis Research UK said: “Although modern treatments have changed the outcome for many patients with rheumatoid arthritis, firstly not all patients respond to them and secondly, even in those patients who do respond in some way, we can’t completely get rid of the inflammation that damages their joints.

“This research is very exciting, as although it is in its early stages, if it can be transferred to humans it could shut down the inflammation that causes rheumatoid arthritis.”

The next stage of the work is to engineer PS372424 to improve its drug-like properties with a view to getting it ready for clinical trial.

  • Additional
  • References
  • Citations

A CXCR3 agonist prevents human T cell migration in a humanized model of arthritic inflammation. Graeme O’Boyle, Christopher Fox, Hannah R Walden, Joseph DP Willet, Emily R Mavin, Dominic W Hine, Jeremy M Palmer, Catriona E Barker, Christopher A Lamb, Simi Ali, John A Kirby. PNAS MS# 2011-18104R

Newcastle University

Please use one of the following formats to cite this article in your essay, paper or report:

MLA


APA


Please note: If no author information is provided, the source is cited instead.


Add Your Opinion On This Article

‘Preventing Damaging White Blood Cells From Entering The Joints Offers Potential Strategy For Treating Rheumatoid Arthritis’

Please note that we publish your name, but we do not publish your email address. It is only used to let
you know when your message is published. We do not use it for any other purpose. Please see our privacy policy for more information.

If you write about specific medications or operations, please do not name health care professionals by name.

All opinions are moderated before being included (to stop spam)

Contact Our News Editors

For any corrections of factual information, or to contact the editors please use our feedback form.

Please send any medical news or health news press releases to:

Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care
professional. For more information, please read our terms and conditions.

MediLexicon International Ltd Logo

Privacy Policy |
Terms and Conditions

MediLexicon International Ltd
Bexhill-on-Sea, United Kingdom
MediLexicon International Ltd © 2004-2012 All rights reserved.

Everyday Health Network

Specifications of JSB B S08 Back Support Plus Massager (32″

Rs. 1469

Summary of JSB B S08 Back Support Plus Massager (32″ – 38″, Brown)

Key Features

Infrared Heating Pad

Belt with Steel Strips

Relieves Back Pain

Anion/Thermal Material

Belt designed to take the shape of lower backs

Pad with Permanent Magnets for Back Relieve

You can take charge of your back pain with the JSB-BS09 Back Support which also works as a massager. One unique feature which the JSB back support massager provides, is the Infrared heat pad that comes with it. This JSB back support brings about remedial solution to your back, lumbar and hip pain.

Build

Designed and conceptualized for bringing relief and proper posture, this Back support massager is very effective as it comes with two parts; the Back Support or the Traction Belt and the Infrared Heating Pad. Each element functions thoroughly to maintain correct posture of the body and alleviate back aches.

The Back Support belt is equipped with contoured steel strips, which are specially designed to take the shape of your lower back, thereby giving an ideal support. It’s highly elastic and breathable fabric accommodates all waist sizes. The Infrared Heating pad is detachable and uses infrared, anion and thermal material which on coming in contact with your body, gives a soothing heating effect. In addition, this pad is fitted with permanent magnets that helps relieve back pain.

Performance

As the saying goes, “Maintain a healthy posture to maintain a healthy back.” This is exactly what the back support belt helps you to achieve. The Back Support or the Lumbar Traction belt realigns your spine that relieves pain and maintains proper posture of your body, preventing you from slouching. The Infrared heating pad generates infrared heat that penetrates deep into the tissues of your lower back thus increasing your blood flow and soothing your back. This pad also relaxes your lower back muscles for greater flexibility and relief.

Light weight and flexible, this Back support plus massager is incredibly easy to use. All you need to do is, strap the belt around your body in order to attain the soothing effect. The JSB-BS09 Back Support is portable and manageable hence giving you the freedom to carry it around with you.

top

IN THE BOX

Sales Package:    Main Unit, Far infrared heat pad, Double lock belt, User Manual

PRODUCT DETAILS

Type: Lower back

Variant:      32″ – 38″

Model Name:      Back Support Plus

Color:        Brown

Model ID:  B S08

Brand:        Jsb

WARRANTY

1 Year Jsb India Warranty and Free Transit Insurance. See Details

Guaranteeing Free Colorectal Cancer Screening For All Medicare Beneficiaries

Main Category: Colorectal Cancer
Also Included In: Medicare / Medicaid / SCHIP
Article Date: 05 Mar 2012 – 0:00 PST

email icon email to a friend   printer icon printer friendly   write icon opinions  

<!– rate icon rate article

Patient / Public:not yet rated

Healthcare Prof:not yet rated

Colonoscopy for colorectal cancer screening saves lives, but a loophole in current Medicare law may cause patients to think twice before undergoing this vital test. Legislation just introduced seeks to ensure that colorectal cancer screening for all Medicare beneficiaries is free, as intended.

The Patient Protection and Affordable Care Act waives the coinsurance and deductible for many cancer screening tests i, including colonoscopy, sigmoidoscopy and fecal occult blood testing (FOBT), which screen for colorectal cancer. Colonoscopy is a unique screening test because gastroenterologists are able to remove precancerous polyps and small cancers during the screening procedure. Under Medicare billing rules, removal of any polyp reclassifies the screening as a therapeutic procedure, for which patients will receive an unexpected coinsurance bill.

The Removing Barriers to Colorectal Cancer Screening Act of 2012 introduced today by Rep. Charlie Dent, R-PA, waives the coinsurance for a screening colonoscopy regardless of whether a polyp or lesion is found. Under current Medicare policy, the beneficiary deductible is waived regardless of whether a polyp or lesion is found. Congressman Dent’s bill applies the same rational policy to beneficiary coinsurance.

The American Cancer Society Cancer Action Network (ACS CAN), the American Gastroenterological Association (AGA) and the American Society for Gastrointestinal Endoscopy (ASGE) have been advocating for the past year and half that Congress corrects this “cost-sharing” problem, which continues to cause confusion for patients and providers.

Cost sharing creates financial barriers, which could discourage the use of colonoscopy. The Removing Barriers to Colorectal Cancer Screening Act of 2012 is critical to achieving higher screening rates and reducing the incidence of colorectal cancer. Almost 38 percent of U.S. adults age 50 and older have never been screened, despite the fact that removing precancerous polyps cuts the death rate from colorectal cancer by half.


Christopher W. Hansen, president, ACS CAN

“I commend Representative Dent for this important effort to ensure that everyone has access to life saving cancer screenings, without regard to their ability pay. Too many Americans are going without lifesaving screenings because they cannot afford it. We urge Congress to help stop a cancer that can be prevented in many cases.”


Lawrence S. Kim, MD, AGAF, Community Private Practice Councillor

“The rate of colorectal cancers and deaths can be decreased through the increased use of screening. However, a majority of Americans are still not participating in these lifesaving tests. The Removing Barriers to Colorectal Cancer Screening Act of 2012 will provide consistency and security for patients seeking colorectal cancer screenings by eliminating financial barriers and removing the confusion facing patients and their physicians over the current health-care policy. The bill introduced by Rep. Dent will help us to continue to increase the strides being made in colorectal cancer screening and, most importantly, save lives.”


Gregory G. Ginsberg, MD, FASGE, president, American Society for Gastrointestinal Endoscopy

“Colorectal cancer is a largely preventable disease. The greatest benefit of colonoscopy screening is removing polyps that are discovered during screening and by so doing, significantly decreasing the risk for later cancer development. Converting a screening procedure that is fully covered by insurance with no cost-sharing, to one that does require cost-sharing by the patient after a polyp is found, is both a barrier to screening and inconsistent with the goal of the preventive services provision. We call upon Congress to pass this bill to fully eliminate the cost burden of colonoscopy colorectal cancer screening by waiving cost-sharing in the event that a polyp or cancer is removed.”

  • Additional
  • References
  • Citations

Please use one of the following formats to cite this article in your essay, paper or report:

MLA


APA


Please note: If no author information is provided, the source is cited instead.


Add Your Opinion On This Article

‘Guaranteeing Free Colorectal Cancer Screening For All Medicare Beneficiaries’

Please note that we publish your name, but we do not publish your email address. It is only used to let
you know when your message is published. We do not use it for any other purpose. Please see our privacy policy for more information.

If you write about specific medications or operations, please do not name health care professionals by name.

All opinions are moderated before being included (to stop spam)

Contact Our News Editors

For any corrections of factual information, or to contact the editors please use our feedback form.

Please send any medical news or health news press releases to:

Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care
professional. For more information, please read our terms and conditions.

MediLexicon International Ltd Logo

Privacy Policy |
Terms and Conditions

MediLexicon International Ltd
Bexhill-on-Sea, United Kingdom
MediLexicon International Ltd © 2004-2012 All rights reserved.

Everyday Health Network

Specifications of Vital Automatic Digital Bp Monitor (Medium Cuff (22-32cm), Off White)

Rs. 999

Summary of Vital Automatic Digital Bp Monitor (Medium Cuff (22-32cm), Off White)

Key Features

Pulse Rate Indicator

Memory Recall

One Touch Operation

Digital Sensor

Auto Shut off Function

Clinically Proven

4 AA Battery Operated

If you choose self-care and personal monitoring to keep a check on your health then Vital Automatic Digital BP Monitor would be suitable for you. This Vital digital BP monitor provides professional accuracy at the confines of your home. Your apprehension regarding the accuracy of this monitor will linger no more, as this BP monitor is clinically proven.

The Digital Blood Pressure Monitor by Vital features a fully automatic operation providing quick and accurate readings with its easy one touch operation. The Auto-off function provided by the digital BP monitor adds to its efficiency and unprecedented functioning.

Build

Simple and easy to use, the Vital automatic BP monitor has a main unit with a one touch operation button and alongside also displays a large LCD display that enhances visibility. The medium sized cuff that comes with the BP monitor can be attached with ease and comfort. The pump is internally built that enables inflation and deflation of the cuff.

Performance and Feature

Using digital sensor, this Vital BP monitor supports automatic inflation and deflation which eventually provides readings automatically in a digitized format. With an accuracy rate of +/- 3mmHg for deriving blood pressure and +/- 5% of reading for pulse rates, this BP monitor simultaneously displays systolic and diastolic pressure along with pulse rates. The Automatic Vital BP monitor provides a measurement range from 40 to 260 mmHg for pressure and 40 to 160 beats per minute for pulse. The digital BP monitor runs with 4 AA replaceable batteries.

top

IN THE BOX

Sales Package:    Main unit, Medium Cuff, 4 AA batteries, Instruction manual

PRODUCT DETAILS

Type: Upper Arm

Variant:      Medium Cuff (22-32cm)

Color:        Off White

Model ID:  Automatic Digital

Brand:        Vital

DEVICE CHARACTERISTICS

Memory Function:       Yes

Pulse Rate Indicator:    Yes

Display:     LCD

MEASUREMENT

Measurement Method: Digital Sensor

Measurement Accuracy Pressure(mmHg):       ±3 mmHg

Measurement Range Pressure(mmHg) (Min):  40 mmHg

Measurement Range Pressure(mmHg) (Max): 260 mmHg

Measurement Range Pulse(beats/min) (Max):  160 beats/min

Measurement Range Pulse(beats/min) (Min):  40 beats/min

Measurement Accuracy Pulse(% of reading):  ±5 % of reading

POWER REQUIREMENTS

No. of Battery:    4

Power Source:    Battery

Battery Type:       AA

WARRANTY

1 Year Vital India Warranty and Free Transit Insurance. See Details

Specifications of Omron HEM 4030 Upper Arm Bp Monitor (Medium Cuff (22-32cm), White)

Rs. 1099

Key Features

Hypertension Indicator

14 Readings Memory

Semi-automatic

LCD Display

3 Fold Display with Systolic/Diastolic and Puse Rates

4 AAA Battery Operated

Clinically Validated

Ideally suited for measuring blood pressure levels in the confines of one’s home, Omron HEM 4030 upper arm BP monitor, a semi-automatic BP monitor is accurate and reliable. This Omron 4030 blood pressure monitor is designed according to the European Standard EN 1060 and fulfills the provisions of EC directive 93/42/EEC thus assuring consistent and genuine results. Moreover, the accuracy of this blood pressure monitor has been carefully tested and is designed for a long service life.

Apart from offering blood pressure and pulse readings, this semi-automatic BP monitor by Omron also incorporates a hypertension indicator that is capable of detecting the presence of hypertension in a patient.

Build

Keeping ease of use and comfort aspects in mind, the HEM 4020 Omron BP monitor is ergonomically designed. The body of the Omron semi-automatic BP monitor comprises of three components; the display panel, the cuff and the inflation bulb. The display panel is composed of a clear and easy to read LCD display and control buttons. The LCD screen simultaneously displays both systolic and diastolic blood pressure readings as well as pulse readings in a digitized format.

The HEM 4030 BP monitor provides a medium sized cuff made from nylon and polyester. The cuff is comfortable and easy to attach. Manually operated, the inflation rubber bulb is easy to squeeze enabling inflation and deflation appropriately at an optimum level.

Performance and Features

This semi-automatic blood pressure monitor by Omron provides accurate readings using the Oscillometric method. The cuff inflates by squeezing the rubber bulb and automatically deflates once you stop squeezing the inflation bulb, after which your blood pressure readings are displayed automatically in a digitized three fold display. The Omron blood pressure monitor displays a range from 0 to 299 mmHg for pressure readings and 40 to 180 beats/minute for pulse rates.

The measurement accuracy rate is recorded at +/-3 mmHg for pressure readings and +/-5% of reading for pulse readings. The monitor features a memory that enables you to keep track of 21 sets of readings. Battery operated, this HEM 4030 BP monitor is powered by 4 AAA batteries. When not in use, you can safely keep the 4030 Omron blood pressure monitor in the storage case that comes with it.

top

IN THE BOX

Sales Package:    Main unit, Medium Cuff, Instruction manual, 4 AAA batteries, Storage case, Inflation bulb

PRODUCT DETAILS

Type: Upper Arm

Variant:      Medium Cuff (22-32cm)

Model Name:      Upper Arm

Color:        White

Model ID:  HEM 4030

Brand:        Omron

DEVICE CHARACTERISTICS

Memory Function:       Yes

Pulse Rate Indicator:    Yes

Display:     LCD

MEASUREMENT

Measurement Method: Oscillometric Method

Measurement Accuracy Pressure(mmHg):       ±3 mmHg

Measurement Range Pressure(mmHg) (Min):  0 mmHg

Measurement Range Pressure(mmHg) (Max): 299 mmHg

Measurement Range Pulse(beats/min) (Max):  180 beats/min

Measurement Range Pulse(beats/min) (Min):  40 beats/min

Measurement Accuracy Pulse(% of reading):  ±5 % of reading

POWER REQUIREMENTS

No. of Battery:    4

Power Source:    Battery

Battery Type:       AAA

WARRANTY

1 Year Omron India Warranty and Free Transit Insurance. See Details

ARE YOU READY?

CARITAS Health Card 01

How FINANCIALLY SECURED are you?

Getting sick can be very expensive. You can fall into debt, sell hard-earned property, and deplete your bank account.

If we can invest in gadgets, cars, and other properties, why not in HEALTH CARE COVERAGE?

Do you currently have an HMO card?

Are you tired of paying for the yearly renewal of your health card?

 

Introducing: The first in the market, the CARITAS HEALTH SHIELD 5-years-to-pay health card with another 5 years of coverage for FREE!

A ONE-OF-A-KIND HEALTH CARE INVESTMENT PACKAGE

  • Comprehensive health care program
  • Five (5) years savings and ten (10) or more years coverage
  • Increasing benefit every year, but fixed premium (no worries about inflation)
  • Choice of Money Back or leave it as Medical Fund while it earns up to 8% annually
  • Four-way Insurance coverage
  • Transferable anytime
  • Assignable up to the 2nd degree of consanguinity

From Health Crisis to Financial Crisis

Difference of Caritas vs other HMOs

Health Insurance 101

Advantage of Caritas

 

Killed by Bill

Like this:

  • Health Counselor LEI


Tell me how I can help you secure your future =) Cancel reply

Gravatar

WordPress.com Logo

Twitter picture

Facebook photo

Connecting to %s

How Up-to-Date is Your Company??

We all strive to ensure our businesses stand apart from the crowd. Going above and beyond is a requirement now more than ever if you want to retain your current customer base in an increasingly competitive market. For many hospitals, doctor’s offices, gymnasiums and various retail shopping outlets, this means keeping your equipment fresh and updated.

When you pull up to an ER, what is one of the first things they might do? Put you in a wheelchair, of course. If that wheelchair is old and worn, it might appear dirty and leave a patient with a bad first impression on their experience. If, however, the wheelchair is well-kept and state of the art instead, they will probably breathe just a bit easier knowing they are in a hospital that pays attention to the details.

This is just an example of course. You can apply the same principle to almost every item in your office. Take a look around and consider upgrading or replacing some of those staples that have been hanging around a day or two past their prime. Your profit margins will thank you.

In the meantime, if you are interested in updating your wheelchairs, please take a look at one of the models we offer, the Medline Excel K1 Basic Model. Please click here to view features.