Ferno-Washington, Inc.

Summary

Ferno-Washington, Inc. (Ferno) is engaged in the manufacture and distribution of professional emergency, mortuary, and healthcare products. The company is principally focused on the patient handling solutions for emergency, mortuary, aviation, military and rescue. Ferno offers a wide range of products in the areas of patient transport solutions, oxygen and airway management, backboards and immobilization, splinting devices, trauma bags and stretchers. The company operates its business across Americas, Europe, Africa, Middle East, Russia and Asia Pacific. The company is headquartered in Ohio, the US.

GlobalData’s Ferno-Washington, Inc. – Strategic SWOT Analysis Review provides a comprehensive insight into the company’s history, corporate strategy, business structure and operations. The report contains a detailed SWOT analysis, information on the company’s key employees, key competitors and major products and services.

This up-to-the-minute company report will help you to formulate strategies to drive your business by enabling you to understand your partners, customers and competitors better.

Scope

– Business description – A detailed description of the company’s operations and business divisions.
– Corporate strategy – GlobalData’s summarization of the company’s business strategy.
– SWOT analysis – A detailed analysis of the company’s strengths, weakness, opportunities and threats.
– Company history – Progression of key events associated with the company.
– Major products and services – A list of major products, services and brands of the company.
– Key competitors – A list of key competitors to the company.
– Key employees – A list of the key executives of the company.
– Executive biographies – A brief summary of the executives’ employment history.
– Key operational heads – A list of personnel heading key departments/functions.
– Important locations and subsidiaries – A list of key locations and subsidiaries of the company, including contact details.
– Key manufacturing facilities – A list of key manufacturing facilities of the company.

For more information, please visit:

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Vivostat AS

Summary

Vivostat A/S (Vivostat) is a privately-held medical device company principally engaged in the research, production and sale of medical devices. The company focuses on improving the quality of surgical sealant and wound care procedures. The company is chiefly into the development of Vivostat System, a fully automated system for on site preparation and application of patient derived fibrin sealant. Its products are used principally in cardiac, thoracic and hepatic surgery. The company markets its products to surgical departments and wound care centers in Europe and Asia. The companys research and development (RD) activity is principally into developing novel equipment for a more safe and rapid recovery for the patients in critical and delicate surgeries. Vivostat is headquartered in Alleroed, Denmark.

GlobalData’s Vivostat AS – Strategic SWOT Analysis Review provides a comprehensive insight into the company’s history, corporate strategy, business structure and operations. The report contains a detailed SWOT analysis, information on the company’s key employees, key competitors and major products and services.

This up-to-the-minute company report will help you to formulate strategies to drive your business by enabling you to understand your partners, customers and competitors better.

Scope

– Business description – A detailed description of the company’s operations and business divisions.
– Corporate strategy – GlobalData’s summarization of the company’s business strategy.
– SWOT analysis – A detailed analysis of the company’s strengths, weakness, opportunities and threats.
– Company history – Progression of key events associated with the company.
– Major products and services – A list of major products, services and brands of the company.
– Key competitors – A list of key competitors to the company.
– Key employees – A list of the key executives of the company.
– Executive biographies – A brief summary of the executives’ employment history.
– Key operational heads – A list of personnel heading key departments/functions.
– Important locations and subsidiaries – A list of key locations and subsidiaries of the company, including contact details.
– Key manufacturing facilities – A list of key manufacturing facilities of the company.

For more information, please visit:

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Symphogen AS

Summary

Symphogen A/S (Symphogen) is a privately-held biopharmaceutical company. It is engaged in development of therapeutic polyclonal antibodies (pAb), a new class of biopharmaceuticals, for the treatment of serious human diseases. The company is developing antibody therapeutics using its proprietary Symplex discovery and Sympress manufacturing technology platforms. Its product pipeline includes Rozrolimopab/ ITP, Rozrolimopab / HDN, Sym002, Sym003, Sym004, Sym005, Sym006, Sym007, Sym008, Sym009 and Sym011. The companys technology is validated through corporate partnerships with pharmaceutical and biotech companies in the US, Europe and Japan. The company is also located in Princeton, New Jersey, the US. Symphogen is headquartered in Lyngby, Denmark.

Symphogen AS Key Recent Developments

Apr 19, 2011: Symphogen Announces Management Changes
Apr 15, 2011: Symphogen Announces Senior Management Changes
Jul 13, 2010: Symphogen Receives New US Patent Covering Symplex Technology For Antibody Discovery
Apr 26, 2010: Symphogen Announces Publication Of Sympress II Production System In Molecular Biotechnology
Apr 01, 2010: Symphogen Begins Sym004 Phase 1/2 Trial

GlobalData’s Symphogen AS – Strategic SWOT Analysis Review provides a comprehensive insight into the company’s history, corporate strategy, business structure and operations. The report contains a detailed SWOT analysis, information on the company’s key employees, key competitors and major products and services.

This up-to-the-minute company report will help you to formulate strategies to drive your business by enabling you to understand your partners, customers and competitors better.

Scope

– Business description – A detailed description of the company’s operations and business divisions.
– Corporate strategy – GlobalData’s summarization of the company’s business strategy.
– SWOT analysis – A detailed analysis of the company’s strengths, weakness, opportunities and threats.
– Company history – Progression of key events associated with the company.
– Major products and services – A list of major products, services and brands of the company.
– Key competitors – A list of key competitors to the company.
– Key employees – A list of the key executives of the company.
– Executive biographies – A brief summary of the executives’ employment history.
– Key operational heads – A list of personnel heading key departments/functions.
– Important locations and subsidiaries – A list of key locations and subsidiaries of the company, including contact details.
– Key manufacturing facilities – A list of key manufacturing facilities of the company.

For more information, please visit:

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Bio-Gate Ag (BIG)

Summary

Bio-Gate AG (Bio-Gate) is a German based medical technology company principally involved in the development of silver technology and manufacturing of antimicrobial agents. The different technologies are used to refine cosmetics, consumer goods and industrial products. The company offers the plasma coating through silver technology under the brand name, Hyprotect and antimicrobial agents under the brand name HyMedic, MicroSilver BG and MicroSilver BG-Tec that are used in endowing the antimicrobial property to products and materials. In addition, the company offers services like biological screening, antimicrobial testing, product registration support and microbiological consulting services. Bio-Gate along with its subsidiaries markets the products and services to manufacturers of medical equipments, electronic goods, transportation, industrial plants, white goods, textiles, skin care products in the US and European countries. The company is headquartered in Nuremberg, Germany.

Bio-Gate Ag Key Recent Developments

Aug 31, 2011: Bio-Gate Reports Revenues Of €1m In H1 2011
May 04, 2011: Bio-Gate Announces Resignation Of Dr Michael Wagener From Board
Feb 09, 2011: NPPD Sets Transmission Line Public Hearing On February 22 In Broken Bow, Nebraska

This comprehensive SWOT profile of Bio-Gate Ag provides you an in-depth strategic SWOT analysis of the company’s businesses and operations. The profile has been compiled by GlobalData to bring to you a clear and an unbiased view of the company’s key strengths and weaknesses and the potential opportunities and threats. The profile helps you formulate strategies that augment your business by enabling you to understand your partners, customers and competitors better.

The profile contains critical company information including:

– Business description – A detailed description of the company’s operations and business divisions.
– Corporate strategy – Analyst’s summarization of the company’s business strategy.
– SWOT Analysis – A detailed analysis of the company’s strengths, weakness, opportunities and threats.
– Company history – Progression of key events associated with the company.
– Major products and services – A list of major products, services and brands of the company.
– Key competitors – A list of key competitors to the company.
– Key employees – A list of the key executives of the company.
– Executive biographies – A brief summary of the executives’ employment history.
– Key operational heads – A list of personnel heading key departments/functions.
– Important locations and subsidiaries – A list and contact details of key locations and subsidiaries of the company.
– Key manufacturing facilities – A list of key manufacturing facilities of the company.
– Detailed financial ratios for the past five years – The latest financial ratios derived from the annual financial statements published by the company with 5 years history.
– Interim ratios for the last five interim periods – The latest financial ratios derived from the quarterly/semi-annual financial statements published by the company for 5 interims history.

For more information, please visit:

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Beckman Coulter, Inc.

Summary

Beckman Coulter, Inc. (Beckman) is principally engaged in the manufacture and marketing of biomedical laboratory instruments, software and supplies that simplify, automate and innovate complex biomedical tests. Its products are used in a wide range of applications such as medical research, clinical trials and drug discovery, and diagnostic laboratories in hospitals. The company operates through two reportable business segments, namely, Clinical Diagnostics and Life Science. The company has its operations in the US, Canada, Europe and Asia. Its products are sold in over 160 countries worldwide. The company has an installed base of over 200,000 clinical and research systems operating in laboratories around the world. Beckman is headquartered in California, the US.

On June 30, 2011, Danaher corporation completed the acquisition of Beckman Coulter, Inc. and merged Djanet Acquisition Corp. into Beckman Coulter, Inc, as a result of which Beckman has become an indirect wholly owned subsidiary of Danaher.

Beckman Coulter, Inc. Key Recent Developments

Jul 15, 2011: GreenHouse Holdings To Provide Auto Demand Response Services To Beckman Coulter
Mar 02, 2011: Brower Piven Announces Class Action Lawsuit In Connection With Acquisition Of Beckman Coulter By Danaher
Oct 27, 2010: Beckman Coulter Reports Net Earnings Of $67 Million In Q3 2010
Sep 07, 2010: Beckman Coulter Announces Resignation Of Scott Garrett As Chairman, President And CEO
Sep 03, 2010: Robbins Geller Files Class Action Suit Against Beckman Coulter

GlobalData’s Beckman Coulter, Inc. – Strategic SWOT Analysis Review provides a comprehensive insight into the company’s history, corporate strategy, business structure and operations. The report contains a detailed SWOT analysis, information on the company’s key employees, key competitors and major products and services.

For more information, please visit:

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Coloplast AS (COLO B)

Summary

Coloplast A/S (Coloplast) is a medical device company engaged in the development, manufacture and sale of products and services in the field of medical care. Its products cater to customers’ needs in the areas of ostomy care, urology and continence care, and wound and skin care. The company’s research and development (RD) activities focus on clinical studies and innovative technological advances in wound care and urology care. Coloplast supplies its products through subsidiaries and distributors to numerous hospitals, institutions, wholesalers and retailers internationally. The company classifies its geographical operations into three regions, namely, Europe, Americas and Rest of the world. Coloplast is headquartered in Humlebaek, Denmark.

Coloplast AS Key Recent Developments

Aug 17, 2011: Coloplast Reports Revenues Of DKK2.6 billion In Q3 Fiscal 2011
May 04, 2011: Coloplast Reports Revenues Of DKK2.5 Billion In Q2 Fiscal 2011
Jan 25, 2011: Coloplast Reports Revenues Of DKK2.5 Billion In Q1 Fiscal Year Ended 2011
Nov 22, 2010: Coloplast Reports Revenues Of DKK9.53 Billion In Fiscal 2010
Aug 19, 2010: Coloplast Reports Net Profit Of DKK337 Million In Q3 Fiscal 2010

This comprehensive SWOT profile of Coloplast AS provides you an in-depth strategic SWOT analysis of the company’s businesses and operations. The profile has been compiled by GlobalData to bring to you a clear and an unbiased view of the company’s key strengths and weaknesses and the potential opportunities and threats. The profile helps you formulate strategies that augment your business by enabling you to understand your partners, customers and competitors better.

The profile contains critical company information including:

– Business description – A detailed description of the company’s operations and business divisions.
– Corporate strategy – Analyst’s summarization of the company’s business strategy.
– SWOT Analysis – A detailed analysis of the company’s strengths, weakness, opportunities and threats.
– Company history – Progression of key events associated with the company.
– Major products and services – A list of major products, services and brands of the company.
– Key competitors – A list of key competitors to the company.
– Key employees – A list of the key executives of the company.
– Executive biographies – A brief summary of the executives’ employment history.
– Key operational heads – A list of personnel heading key departments/functions.
– Important locations and subsidiaries – A list and contact details of key locations and subsidiaries of the company.
– Key manufacturing facilities – A list of key manufacturing facilities of the company.
– Detailed financial ratios for the past five years – The latest financial ratios derived from the annual financial statements published by the company with 5 years history.
– Interim ratios for the last five interim periods – The latest financial ratios derived from the quarterly/semi-annual financial statements published by the company for 5 interims history.

For more information, please visit:

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William Demant Holding AS (WDH)

Summary

William Demant Holding A/S (WDH) engages in the development, manufacture and distribution of innovative and high-technology solutions for hearing aids and communication of individuals. The company focuses on three business areas, Hearing Aids, Diagnostic Instruments and Personal Communication. It operates through a three reportable business segments namely development, manufacturing and sale of products and equipments developed for people’s hearing and communication. The company include Hearing Aids, Diagnostic Instruments and Personal Communication. The group classifies its geographic segments into five regions namely Europe, the North America, Pacific Rim, Asia, and Other countries. It has about 60 wholly owned subsidiaries. The company Research and Development (RD) is principally into the development of new business concepts, prototype construction. WDH is headquartered in Smorum, Denmark.

This comprehensive SWOT profile of William Demant Holding AS provides you an in-depth strategic SWOT analysis of the company’s businesses and operations. The profile has been compiled by GlobalData to bring to you a clear and an unbiased view of the company’s key strengths and weaknesses and the potential opportunities and threats. The profile helps you formulate strategies that augment your business by enabling you to understand your partners, customers and competitors better.

The profile contains critical company information including:

– Business description – A detailed description of the company’s operations and business divisions.
– Corporate strategy – Analyst’s summarization of the company’s business strategy.
– SWOT Analysis – A detailed analysis of the company’s strengths, weakness, opportunities and threats.
– Company history – Progression of key events associated with the company.
– Major products and services – A list of major products, services and brands of the company.
– Key competitors – A list of key competitors to the company.
– Key employees – A list of the key executives of the company.
– Executive biographies – A brief summary of the executives’ employment history.
– Key operational heads – A list of personnel heading key departments/functions.
– Important locations and subsidiaries – A list and contact details of key locations and subsidiaries of the company.
– Key manufacturing facilities – A list of key manufacturing facilities of the company.
– Detailed financial ratios for the past five years – The latest financial ratios derived from the annual financial statements published by the company with 5 years history.
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For more information, please visit:

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Instrumentation Laboratory Company

Summary

Instrumentation Laboratory Company (IL) engages in the development, manufacture and distribution of laboratory products for the in vitro diagnostic market. The company develops products such as reagents, centrifugal analyzers, enhanced solid state fluidics, CO-Oximetry, calibrators, controls and coagulation analyzers that are used in critical care and hemostasis, and in laboratories. It offers microcoagulation, blood testing, quality control, and coagulation analyzer systems; and IMPACT Report Writer, a windows application that consolidates data from the analyzers. The company has operations in the UK, France, Italy, Uruguay, Belgium, Germany, Mexico, Japan, Austria, the Netherlands, Hong Kong, and the US, among others. It is a subsidiary of Werfen Group. IL is headquartered in Bedford, Massachusetts, the US.

Instrumentation Laboratory Company Key Recent Developments

Jul 28, 2011: Hospitals, Healthcare Providers To Benefit From New Premier Agreements For Blood Gas Analyzers
Apr 27, 2011: Instrumentation Laboratory Appoints Ramon E Benet As New CEO
Feb 24, 2010: Instrumentation Laboratory Gets FDA, Health Canada Nod For HemosIL Assay
Feb 01, 2010: Instrumentation Laboratory Wins New Contract With Amerinet
Jan 07, 2010: Instrumentation Laboratory Wins New Contract With Novation

GlobalData’s Instrumentation Laboratory Company – Strategic SWOT Analysis Review provides a comprehensive insight into the company’s history, corporate strategy, business structure and operations. The report contains a detailed SWOT analysis, information on the company’s key employees, key competitors and major products and services.

This up-to-the-minute company report will help you to formulate strategies to drive your business by enabling you to understand your partners, customers and competitors better.

Scope

– Business description – A detailed description of the company’s operations and business divisions.
– Corporate strategy – GlobalData’s summarization of the company’s business strategy.
– SWOT analysis – A detailed analysis of the company’s strengths, weakness, opportunities and threats.
– Company history – Progression of key events associated with the company.
– Major products and services – A list of major products, services and brands of the company.
– Key competitors – A list of key competitors to the company.
– Key employees – A list of the key executives of the company.
– Executive biographies – A brief summary of the executives’ employment history.
– Key operational heads – A list of personnel heading key departments/functions.
– Important locations and subsidiaries – A list of key locations and subsidiaries of the company, including contact details.
– Key manufacturing facilities – A list of key manufacturing facilities of the company.

For more information, please visit:

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What Causes Leg Pain?

Editor’s Choice
Main Category: Pain / Anesthetics
Also Included In: Sports Medicine / Fitness;  Arthritis / Rheumatology
Article Date: 21 Feb 2012 – 13:00 PST

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Patient / Public:5 stars

5 (1 votes)

Healthcare Prof:5 stars

5 (2 votes)

Leg pain refers to any kind of pain that occurs between the heels and the pelvis. There are many reasons for leg pain, and not all of them are caused by a problem that originates in the leg; some injuries or spinal problems can cause aches and pains in the leg(s).

Leg pain can be long-term, transitory, intermittent, acute, or slowly progressive. Pain may affect just part of the leg, such as the knee, or the whole limb. Leg pain may be felt as tingling, sharp, dull, an ache, or a stabbing sensation.

Some leg pains may be just a nuisance, in some cases the cause may never be found, other leg pains may be a sign of a more serious disease or condition, even a life-threatening one.

Leg pain caused by trauma

Trauma has a medical and psychiatric meaning. In this text, it refers to the medical meaning. Trauma is a serious injury, wound or shock, and can include broken bones, damage to bones, damage to muscles, joint injury, or a combination.

Even trauma to the back, if the sciatic nerve becomes inflamed, can cause pain that makes its way down the leg along the sciatic nerve (sciatica). Overusing some part of the leg can also lead to injuries.

  • Fractures – fracture refers to any kind of break in bone, and sometimes cartilage. Not all bone fractures are caused by trauma – patients with osteoporosis may have such weak bones that they fracture with the minimum of pressure. Fractures are common causes of leg pain, and occur when nerve endings in the tissue that surround the bone (periosteum) send pain messages to the brain. Sometimes, a bone fracture can cause muscles to spasm, which further exacerbates the pain.
  • Shin splints – medically known as medial tibial stress syndrome, refers to pain just behind the tibia (shinbone) or along it. Shin splints occur when too much force bears down on the shinbone and connective tissue that connect muscle to the bone. Runners and those who take part in stop-start activities, such as squash, tennis, soccer or basketball are more likely to suffer from shin splints. Symptoms may include soreness, pain or tenderness, and sometimes mild swelling in the affected area.


    A runner wraps leg in ice to treat shin splints after running 8 kilometers in the 2009 Armed Forces Cross Country Championship

  • Strains and/or sprains – strains are injuries to tendons or muscles, while sprains are injuries to ligaments. Strains occur when you tear, twist, or pull a muscle. People with a sprain commonly experience acute pain, weakness and muscle spasms. Sprains usually occur as a result of trauma, such as a fall. The area may bruise and the pain can be intense, especially when moving.
  • Compartment syndrome – this is when an increase in pressure and swelling affects a compartment (limited space); the blood vessels, nerves and possibly also the tendons that run through the compartment are affected. Symptoms typically include tingling, numbness, sometimes severe pain, as well as loss of movement in a foot. Eventually, in time, the nerve can become compressed, there may be paralysis, contracture, and even death.
  • Bleeding – an injury to the leg that causes internal bleeding can lead to pain. A build-up of blood can press against tissue, bone and nerve endings. Blood itself is irritating, and can cause inflammation, which is painful.

Other causes of leg pain

Peripheral artery disease (PAD), also known as peripheral arterial disease, or peripheral artery occlusive disease, refers to blockages in large arteries which are not located within the brain, coronary, or aortic arch vasculature. PAD can be caused by atherosclerosis, an embolism or thrombus, or any inflammatory process that leads to stenosis (narrowing of a blood vessel).

Put simply, the blood vessels to the leg become narrower, restricting the blood supply. Pain is felt with physical activity. Pain, weakness, numbness, or cramping in muscles caused by decreased blood flow is known as claudication.

Poor blood supply can lead to several complications, such as ulcers, which can be very painful. (Read the “David Dow” story further down)

Deep vein thrombosis – also known as DVT occurs when a thrombus (blood clot) develops in a deep vein, nearly always in a leg. The clot tends to occur in leg veins, such as the femoral or popliteal veins, but can also develop within the pelvis. The thrombus can break off and make its way to the lung, causing a pulmonary embolism.

Some patients may have a DVT and not be aware of it; there are no symptoms. If symptoms do emerge, they will include swelling, pain, tenderness, and warmth in the affected area. Usually, the pain starts in the calf. In some cases the skin may go red, especially at the back of the leg below the knee. Surface veins may become engorged.

Sciatica – this occurs when the sciatic nerve is irritated. Pain radiates from the lower back, all the way down to below the knee, via behind the thigh and buttocks. Sciatica can have a number of causes, such as a herniated disc that presses directly on the nerve. The pain, which can be severe, is sometimes accompanied by numbness, muscular weakness, tingling and problems controlling or moving the leg. When the weather is very cold, pain may become worse.

Peripheral neuropathy – refers to a problem with function of nerves outside the spinal column, such as in the legs. Symptoms include burning pain (especially when lying down), problem with reflexes, numbness, pins and needles, and weakness. Peripheral neuropathy can be caused by certain medications, kidney failure, vitamin deficiency, and diabetes.

In severe cases, the patient’s feet can become too sensitive to touch (even lightly touching the skin hurts). Eventually, the patient may become housebound if shoes and socks cannot be worn and the feet are too sensitive to touch the ground (extreme cases).

Diabetes – patients with diabetes have a higher risk of experiencing leg and/or foot pain – these are due to diabetes complications, such as peripheral neuropathy or some vascular problem that results in poor blood circulation.

Alcoholism – excessive alcohol can have a damaging effect on the brain, peripheral nerves and muscles. Common symptoms linked to alcoholism include (in the leg) burning pain, tingling, muscle weakness, sensitivity to heat, and tingling.

Cancer – the most common symptom of bone cancer is pain. Other cancers, such as prostate cancer that has spread (metastasized), may also cause pain in the pelvic area and upper leg area. Ovarian or cervical cancer may also cause leg pain.

Shingles – symptoms of shingles include pain in various parts of the body, including the legs.

Arthritis – affects the musculoskeletal system, especially the joints. Arthritis is the main cause of disability among individuals aged over 55 years in wealthy nations. It is not a single disease, but a term that covers over 100 medical conditions, of which osteoarthritis is the most common.

  • Osteoarthritis – the cartilage loses elasticity, becomes stiff and consequently damages more easily. The cartilage will gradually wear away in some areas, causing tendons and ligaments to become stretched, resulting in pain. Joints in the leg may start rubbing against each other, causing intense pain.
  • Rheumatoid arthritis – this is a form of arthritis with inflammation. The synovium (synovial membrane) is attacked, causing swelling and pain. Symptoms can come and go, and may include stiffness, swelling, and pain in the joints.

  • Infectious arthritis (sebptic arthritis) – the synovial fluid and tissues of a joint become infected; usually by bacteria, but possibly by a virus or fungus. The pathogen spreads through the bloodstream of nearby infected tissue, and infects a joint. The patient may experience chills, general weakness, fever, problems moving the limb, severe pain in the infected joint, especially when trying to move. The joint will also swell and feel warm.

Myalgia – muscle pain. This could be caused by an infection, overusing or overstretching a muscle or group of muscles. Sometimes it is a symptom of chronic fatigue syndrome.

Muscle cramps – these may be extremely painful and can have many causes, such as not stretching properly, an electrolyte imbalance, exposure to large changes in temperature, or dehydration.

Hamstring injury – this occurs when one of the hamstring muscles is pulled or strained. Hamstring muscles run along the back of the thigh. In some cases, the muscle tears completely or partially. The patient may feel a sharp, sudden pain in the back of the thigh during physical activity. Some describe it as a tearing or popping sensation. A few hours after the injury, there may be some tenderness or swelling, as well as bruising.


Bruising caused by strained hamstring. The horizontal lines were caused by the bandaging

The story of David Dow and his leg pains

David Dow thought his leg pains were due to a back problem. As you will read further on, the pain actually saved his life. David was a seemingly healthy male, aged 57. He suspected nothing serious, and thought that perhaps some back-strengthening exercises with a personal trainer would be good for him.

Workouts were done perfectly, and his back got stronger. However, the leg pain just got worse – so much so, that eventually it became a struggle to make it from his car to the grocery store entrance. David, and also his trainer wondered whether there might be something more serious going on.

He saw his doctor, who ordered some diagnostic tests. It turned out that he had blockages in the blood vessels in his legs. He was astonished to discover that the arteries that went to his lower extremities were almost 100% blocked. Why? The doctor told him that after years of regular smoking, consuming meals high in animal fats, and some other factors, cholesterol, scar tissue, and blood clots accumulated inside the blood vessels.

Most lay people do not associate clogged artery disease and/or arteriosclerosis with the legs, but rather the heart. In David’s case, this was developing all over his body – he had PAD (peripheral arterial disease).

PAD can cause leg pain. In fact, experts say it is an “early warning” that a heart attack or stroke is looming.

James Stanley, M.D., a director of the University of Michigan CVC, and the vascular surgeon who operated on David, said:

“This is the hallmark of a disease that’s all over. It’s like gray hair you don’t just get it on one side of your head. So if you’ve got this kind of blockage in your leg, you’re going to have it other places.”

Dr. Stanley explained that almost one quarter of those with PAD-associated leg pain die within five years, mainly from a heart attack or some other heart problem. Those with David’s symptoms – hardly able to walk to the shop from his car – are even more likely to die within five years.

David was lucky. He was diagnosed and treated in time. He has a bypass operation to open his blocked leg arteries. His doctor says he is fine now.

David said:

“For sure, it’s a wake-up call. You know that old saying, ‘Where there’s smoke, there’s fire’? I’m sure that I not only have the vascular issues in my lower extremities, but I’m sure I have them in other parts of my body.”

David gave up smoking and has adopted some urgently needed lifestyle changes.

Dr. Stanley explained that nearly 30 million Americans have some kind of PAD, and most of them without any symptoms. Nearly one in every five 70 year-old American has PAD. (Link to full article on David Dow and PAD).


PAD can lead to tissue loss, ulcerations, and even gangrene

Written by Christian Nordqvist

Copyright: Medical News Today

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Arthritis and Lupus Linked To Lower Birth Rates

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Academic Journal
Main Category: Lupus
Also Included In: Arthritis / Rheumatology;  Women’s Health / Gynecology
Article Date: 21 Feb 2012 – 10:00 PST

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A multi-center study of a national survey published in Arthritis Care and Research, a journal of the American College of Rheumatology (ACR), has established that over half of women with rheumatoid arthritis (RA) and systematic lupus erythematosus (SLE) have fewer children than desired.

Leading researcher, Kaleb Michaud, Ph.D., assistant professor in the internal medicine department-rheumatology section at the University of Nebraska Medical Center, and his team established that whilst patients’ choices are partly responsible for having smaller family sizes, the survey results suggest that higher infertility rates and miscarriages may also affect the number of babies born to those suffering from these chronic conditions.

According to ACR estimates, almost 322,000 U.S. adults suffer from systemic lupus, a disease whereby the body’s immune system becomes overactive, attacking healthy cells, tissues, or organs, whilst about 1.3 million adult Americans have RA, a chronic autoimmune disease causing painful joint inflammation. Medical evidence has shown that both RA and SLE are more prevalent in women, and given that the disease often starts to occur during a woman’s reproductive years, it can result in problems starting a family.

The study, which was conducted to gain a better insight into reasons of infertility, pregnancy loss and family choice in women with RA and SLE involved surveying 1,017 women registered in the National Data Bank for Rheumatic Diseases, of whom 578 women with RA and 114 with SLE responded.

The researchers categorized the women into three separate groups. Group A consisted of those interested in having children, but who had fewer than planned, Group B consisted of women who wanted children and who had the number of children they planned, and Group C consisted of those who were no longer interested in having children after being diagnosed with RA or SLE.

The results of the study demonstrated that over 60% of participants belonged to Group C, and that 55% of women with RA, and 64% of those with SLE had fewer children than originally planned.

The infertility rate of women with RA in group A was 1.5 times higher, compared with those in group B, however, both groups had similar rates of miscarriage, and even though women with SLE in group A had a comparable number of pregnancies to those in group B, their rate of miscarriage was three times higher. Furthermore, it showed that 42% of women with RA had an overall infertility rate of 42%, and had fewer children than desired.

Women who were diagnosed with RA during their childbearing years had a higher infertility rate, compared with those who were diagnosed after childbearing was complete. There was no substantial increase in fertility in those with SLE, yet women with lupus were observed to have fewer children than desired, which was linked to miscarriage.

Other reasons for fewer pregnancies in women with RA and SLE were reported as the inability to care for their children, adverse effects from medications taken during pregnancy as well as concerns of genetically transmitting the disease to their offspring.

Dr. Michaud said:

“Rheumatoid arthritis and lupus and their treatments can pose major problems for women during pregnancy and can even result in birth defects and spontaneous abortion. We hope this study will bring these reproductive-health concerns to the forefront, especially among women in their childbearing years.”

The researchers indicate that educating patients and raising their awareness of safe medical options during pregnancy, together with effectively controlling these autoimmune diseases will help women to achieve their family planning goals.

Dr. Michaud calls for further studies to investigate the underlying causes of infertility and pregnancy loss in women with RA and SLE.

Written by Petra Rattue

Copyright: Medical News Today

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